A Novel Control Point in Cholesterol Biosynthesis

Sites of control of hepatic cholesterol biosynthesis.

An inhibition in the conversion of mevalonate to cholesterol has been demonstrated in liver of cholesterol-fed rats by both in vitro and in vivo methods. Synthesis decreased to 30% of the control value after 1 week and 20% after 1 month on a 1% cholesterol diet. After a year, synthesis from mevalonate was almost completely inhibited. The rate of conversion of squalene to cholesterol was not con...

Biosynthesis of Cholesterol

Effects of probiotic Lactobacillus paracasei TD3 on moderation of cholesterol biosynthesis pathway in rats

Objective(s): Prevalence of high-fat food consumption, such as fast foods is one of the major causes of hypercholesterolemia, which can lead to cardiovascular diseases. 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and cytochrome P450 7A1 (CYP7A1) are two key genes in cholesterol metabolism. Use of probiotics in the diet is a promising approach for modulation...

Inherited disorders of cholesterol biosynthesis.

Defects of cholesterol biosynthesis comprise a heterogeneous group of disorders, most of which have only been recently described and more are likely to follow in the near future. Mevalonic aciduria (MVA) and hyperimmunoglobulinemia D syndrome (HIDS) are due to allelic defects in mevalonate kinase, an enzyme located proximally in the pathway of cholesterol and nonsterol isoprene biosynthesis. Cl...

A novel method for locating the local terrestrial laser scans in a global aerial point cloud

In addition to the heterogeneity of aerial and terrestrial views, the small scale terrestrial point clouds are hardly comparable with large scale and overhead aerial point clouds. A hierarchical method is proposed for automatic locating of terrestrial scans in aerial point cloud. The proposed method begins with detecting the candidate positions for the deployment of the terrestrial laser scanne...